Cody Pickett, the 49ers’ fourth starting quarterback in five games, made few mistakes in his first start. But he couldn’t spark anything behind San Francisco’s comically inept offensive line, which committed several penalties and rarely allowed Pickett a moment’s peace.

“Cody did a great job with the plays, but it’s tough getting the timing down when you don’t have the same quarterback in practice every week,” receiver Brandon Lloyd said of Pickett, who went 12-of-21 for 102 yards.

“(Pickett) didn’t cause any problems for us,” Strahan said. “It seemed like every time he dropped back, we were successful in putting some pressure on him and hitting him.”

Joe Nedney kicked two field goals for the Niners (2-6), who lost for the sixth time in seven games.

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The 49ers’ offense briefly got going late in the first half, with Pickett scrambling for two first downs before Lloyd took the crowd’s breath away with a one-handed, behind-the-head catch inside the New York 5.

But struggling left tackle Anthony Clement was called for holding on the play — and after consecutive false starts by the line, Pickett’s long pass was intercepted by Brent Alexander.

Manning quickly hit Shockey twice for the Giants’ first TD.

“It is a lack of focus and concentration,” 49ers coach Mike Nolan said of the penalties. “Emotion is a huge part of the game, and you can’t let emotions get the better of you. There’s not a tremendous amount of noise at home. Today, (false starts are) inexcusable.”

San Francisco scored on Nedney’s 48-yard field goal early in the second half, ending nearly 108 scoreless minutes for the Giants’ defense, which shut out Washington last week. Nedney hit a 52-yarder several minutes later.

Notes: San Francisco got four of its nine first downs on penalties. ... Back judge Don Dorkowski injured his calf during the second half, and the game was finished with six officials. ... The Niners had just 10 men on the field for the game’s first play — a 28-yard catch by Shockey.

NFL game stories Quick look at Week 4 games STEELERS 23, RAVENS 20, OT: Baltimore loses first game of season REDSKINS 26, COWBOYS 24: Dallas can't contain Portis in 1st loss BEARS 24, EAGLES 20: Goal-line stand boosts Chicago JETS 56, CARDINALS 35: Favre throws career-high 6 TDs BUCS 30, PACKERS 21: Ryan's 3 FGs lift Tampa CHARGERS 28, RAIDERS 18: San Diego tops rival 10th straight time BILLS 31, RAMS 14: Buffalo 4-0 for first time since 1992 CHIEFS 33, BRONCOS 19: Johnson rushes for 198 yards for K.C. BROWNS 20, BENGALS 12: Anderson throws TD TITANS 30, VIKINGS 17: Tennessee 4-0 for first time ever PANTHERS 24, FALCONS 9: Smith honors Lucas after TD JAGUARS 30, TEXANS 27, OT: Scobey kicks game winner SAINTS 31, 49ERS 17: McAlister scores first TD of year

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