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After a flurry of changes, UFC 146 is officially set.

After a flurry of changes, UFC 146 is officially set.

New York - After a flurry of changes, UFC 146 is officially set.

The domino effect began on Friday when UFC president Dana White announced that Frank Mir would replace Alistair Overeem against Junior dos Santos for the UFC heavyweight title on May 26. Overeem was pulled from the fight after failing a pre-UFC 146 drug test on March 27 because his testosterone to epitestosterone ratio was 14:1, more than twice the limit in Nevada. The Nevada State Athletic Commission's T/E ratio limit is 6:1.

This change set in motion a series of other changes to the card. As a result, Antonio "Bigfoot" Silva will now face Cain Velasquez, Mir's original opponent; Roy Nelson will now face Gabriel Gonzaga; and Shane del Rosario will meet Stipe Miocic.

The only main card fight that wasn't changed was Stefan Struve vs. Mark Hunt.

UFC 146 airs live on pay-per-view from the MGM Grand Garden Arena in Las Vegas.

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