Brittney Griner and the Baylor Bears have one goal this season - a national championship.
Anything less would be a disappointment for the undefeated top-seeded Lady Bears, who are looking to become the seventh school to run through a season unbeaten.
Standing in the way could be the other No. 1 seeds - Stanford, Connecticut and Notre Dame, dominant all season long. The Huskies and Irish both lost competitive games at Baylor this season.
Griner and Baylor, who lost in the regional final last season, could be the first team ever to win 40 games in a year, but coach Kim Mulkey only cares about one thing - a second national title for the school.
"We started hearing about that, and it's never been a goal of ours," Mulkey said of winning 40 games. "Our simple goal is to win a national championship."
The basketball madness gets started Saturday - the first step en route to the Final Four, which begins April 1 in Denver.
The two teams met in November, and Tennessee held an eight-point lead early in the second half before Griner took over en route to a nine-point victory.
The 6-foot-8 phenom has been dominant lately scoring more than 40 points twice in the past 10 games, including a 45-point effort in the Big 12 tournament semifinals this past weekend.
The Lady Vols have won eight national championships but haven't been to the Final Four in three seasons. They pledged at the beginning of the season that they would not go a fourth consecutive year without reaching the Final Four - something they've never done - and would try to win a national title to honor Pat Summitt. The coach announced in August she'd been diagnosed with early onset dementia, Alzheimer's type.
Summitt's squad will face her alma mater - Tennessee Martin - in the opener.
"I like my alma mater," Summitt said. "I like winning and moving on better."
Before a potential matchup with Baylor, Tennessee could meet Delaware and the nation's leading scorer Elena Delle Donne. The 6-5 star is averaging 27.5 points this season and has guided the Blue Hens to a 30-1 mark.
Now they are looking for their first NCAA tournament victory.
Connecticut hopes to win its eighth national championship (tying Tennessee) and will start with a matchup against Prairie View.
UConn coach Geno Auriemma told the Huskies' faithful in the preseason that this team wouldn't win a national championship. But his young team has developed over the past five months, and Connecticut looks poised to make another run after beating Notre Dame for the Big East tournament title.
"If you have to rely just on momentum then you don't have a good enough team," Auriemma said. "We've got to hope we have a good enough team and then rely on momentum as an extra asset."
The Irish also have been focused on winning a title after falling just short last season, losing in the championship game to Texas A&M, which is a No. 3 seed in the Raleigh region. The two teams could meet in the regional final.
Notre Dame, which will open up at home against Liberty, reached the national title game last year by knocking off UConn in the Final Four. It was the fourth straight season that UConn made the Final Four. The two teams, who already have played three times this year, could meet for a fourth time in Denver.
The Cardinal also have advanced four straight seasons to the Final Four, and coach Tara VanDerveer is looking to get her first title in 20 years. She'll begin with a trip East to Norfolk, Va. to face Hampton. Stanford, which has won 28 straight games since its lone loss of the season to Connecticut, hasn't been east of the Rockies since 2001, when they went to Oklahoma.
The nation grieved for those hurt, killed and affected by the Boston Marathon bombings. After one of the suspects was caught on Friday — following a day-long lockdown and manhunt — sports returned to Boston over the weekend.
"Well last year at this time I don't think anyone thought Texas A&M was going to win either," VanDerveer said. "Baylor has had a great year. I think that Brittney Griner is a great player, she's a tremendous talent. We know that every team is beatable. I hope we have a chance to play them. We want to go as far as we can. If that means playing Baylor, we'll be ready."
Standing in the way of a fifth trip to the Final Four could be second-seed Duke, which lost in the ACC tournament quarterfinals. The Blue Devils are led by talented freshman post Elizabeth Williams and sophomore guard Chelsea Grey and will face Samford in the opening round.
Another intriguing team in that region is third-seeded St. John's, which ended UConn's 99-game homecourt winning streak in February. The Red Storm have won 14 of their last 17 games after falling to the Huskies in the semifinals of the Big East tournament. Third seed St. John's faces Creighton in its opener.
Missing from the tournament is North Carolina, which is hosting the first two rounds, but didn't make the field for the first time since 2001.
While the Tar Heels will be missing, three schools - Albany, St. Bonaventure and Florida Gulf Coast - are making their first appearance.
The Bonnies and Eagles will be meeting in the first round.
Duke coach said that after winning his second gold medal in men's basketball would be his Team USA finale. That may not be the case anymore.
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