Barner had an 8-yard touchdown run to close the Ducks to within 38-27 with 12:44 left in the game. The Trojans ate a lot of time up with their next series, but Barkley was intercepted by John Boyett, putting the Ducks in business on their own 40. Oregon scored on James' 1-yard run, and the 2-point conversion pass was ruled good after review to make it 38-35.
"I never felt comfortable," Kiffin said. "You can't get comfortable. They're just so explosive."
It was USC's first victory in the state of Oregon since 2005.
USC has one final game, next week against Los Angeles rival UCLA. The league's southern representative in the inaugural Pac-12 championship is still up for grabs between Arizona State, Utah and UCLA.
The Ducks still need only to win at home next week against Oregon State to clinch the Pac-12 North Division.
After the game, coach Chip Kelly was asked if perhaps Oregon's guard was down against the Trojans after a decisive victory over then-No. 3 Stanford last week.
"I didn't feel like it was a hangover. The credit goes to that other team. That's a good football team," said Kelly, who after the game went to the Trojans locker room to congratulate USC assistant Monte Kiffin, Lane's father.
The loss was Chip Kelly's first at Autzen as Oregon's head coach.
There were cheers before the game started when NBA stars LeBron James, Chris Paul, Dwyane Wade, Chris Bosh, Carmelo Anthony and several others showed up on the sidelines. James and Anthony even tossed around a football.
The players have been working out at Nike headquarters in Beaverton, Ore., just outside of Portland.
The Fighting Irish have a promising future based on coaching, current talent, recruiting, title path, and program power.
CFT: Johnny Manziel nearly transferred out of Texas A&M before the 2012 season after being suspended, according to reports, but he stayed after his successful appeal.
Video: Football from NBC Sports
The Hype: How early is too early for sports scholarships?
There's a disturbing trend afoot in college football -- the offering of scholarships to middle school students. Despite never playing a down of high school football, Lindell Stone, an eighth-grader who already has an offer from UCLA, is the latest hot commodity. Michelle Beadle and Carolyn Manno discuss the absurdity of this trend and consider the possibility of scholarships for embryos
BCS title game
Pregame color, key plays and other moments from 'Bama's blowout win.
Check out the action from the postseason.
Check out which players were best of the best at each position.
Check out some of the college football cheerleaders from across the country.