NEW YORK - No. 4 Andy Murray has made an earlier-than-expected exit from the U.S. Open, losing to No. 25 Stanislas Wawrinka in the third round.

Wawrinka defeated Murray 6-7 (3), 7-6 (4), 6-3, 6-3 on Sunday in Armstrong Stadium.

Murray was a popular pick this year, based on trips to the finals at Flushing Meadows two years ago and this year's Australian Open, along with a win in Montreal last month in which he beat both Rafael Nadal and Roger Federer.

Instead, he makes his second straight early exit from the U.S. Open. Last year, as the No. 2 seed, he was upset in the fourth round by Marin Cilic.

Next, Wawrinka will play 20th-seeded American Sam Querrey in the fourth round.

Querrey is looking to put the "U.S." back in the U.S. Open.

It's been seven years since a man from the United States won the country's most important tennis tournament. Indeed, it's been that long since an American man won any Grand Slam singles title.

Querrey is all-too-aware of such statistics - and the chatter about such droughts. Cheered on by a boisterous, partisan crowd, the 20th-seeded Querrey beat 14th-seeded Nicolas Almagro of Spain 6-3, 6-4, 6-4 Sunday to reach the fourth round at Flushing Meadows for the second time in three years.

"The average sports fan watches the Grand Slams, and they watch on Saturday and Sunday and the semis and the finals," said the 22-year-old Querrey, the youngest man left in the field. "That's what we need to do: We need to get some guys there."

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At the 2009 U.S. Open, zero U.S. men reached the quarterfinals for the first time in the history of an event that began in 1881. This time, of 15 Americans that entered the tournament, there are two who are still around for the fourth round - Querrey and No. 19 Mardy Fish - after No. 18 John Isner lost to No. 12 Mikhail Youzhny of Russia 6-4, 6-7 (7), 7-6 (5), 6-4 despite hitting 33 aces Sunday night.

Isner, best known for winning the longest match in tennis history at Wimbledon in June, got broken early in each of the first two sets, then was down 5-1 in the second, before making things interesting. But Youzhny came up with one of his five aces to end the third-set tiebreaker, then broke the 6-foot-9 Isner again early in the fourth. Youzhny heads to the U.S. Open's fourth round for the first time since he was a semifinalist in 2006.

Querrey never has been to the quarterfinals at a major tournament, nor has his next opponent, No. 25-seeded Stanislas Wawrinka of Switzerland.

Murray's defeat was the only significant surprise on a day that saw No. 1 Rafael Nadal and four other Spaniards advance: No. 8 Fernando Verdasco, No. 10 David Ferrer, No. 23 Feliciano Lopez, and unseeded Tommy Robredo.

"Probably the most difficult tournament for us, no?" Nadal said after beating Gilles Simon of France 6-4, 6-4, 6-2. "So that is very important news for Spanish tennis."

Murray alone bears the burden of Britain's hopes for its first male Grand Slam champion since 1936. He was a popular pick to go far at Flushing Meadows; he was the runner-up at the 2008 U.S. Open and at this year's Australian Open, also on hard courts.

"I have no idea whether I'll win a Grand Slam or not. I want to. But if I never win one, then what? If I give 100 percent, try my best, physically work as hard as I can, practice as much as I can, then that's all I can do," said the 23-year-old Murray, who was treated by a trainer for leg and elbow issues. "It's something I would love to do. It's a very difficult thing. I don't know if I'll win a Grand Slam or not. But I'll give it my best shot."

He served poorly against Wawrinka, putting only half of his first serves in and getting broken eight times. Now Wawrinka will attempt to solve the serve of Querrey, who hit 19 aces at up to 137 mph and never was broken by Almagro.

"He's very dangerous on this surface," Almagro said. "He's in top form right now."

Fish won Saturday to earn a spot in the fourth round, where he will take on No. 3 Novak Djokovic of Serbia.

When Andy Roddick - the American who won the 2003 U.S. Open - briefly dropped to 11th in August, it was the first time since the rankings began in 1973 that there were no U.S. men in the top 10. That alone was enough to cue a new chorus of questions about the state of the game in a nation that produced Pete Sampras and Andre Agassi, Jimmy Connors and John McEnroe.

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"I mean, you always hear that," said Querrey, who grew up in California but now lives in Las Vegas. "It's kind of like any sport. You've got waves where you'll have a group of Americans in the top 10; you might have a couple years where we don't. It's like with the Lakers: They'll win some championships, and (then) they won't make the playoffs. It's just like that."

With Sunday's five Spaniards joining No. 21 Albert Montanes, who won Saturday, that country has six members of the last 16 - tying the record for a country other than the United States at the U.S. Open.

"It's always nice to see all the Spanish winning and being in the last rounds, no?" said Verdasco, who eliminated 2002 Wimbledon runner-up David Nalbandian of Argentina 6-2, 3-6, 6-3, 6-2.

Ferrer beat Daniel Gimeno-Traver of Spain 7-6 (2), 6-2, 6-2; the opponents of Robredo and Lopez retired during their matches. The winners of Nadal vs. Lopez, and Ferrer vs. Verdasco will meet for a semifinal spot.

"I don't really care whom I'm playing against," Nadal said, "if they're all Spaniards."

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