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Andy Roddick reacts after losing a point to Marin Cilic in the final game of their match during the Rogers Cup in Toronto. Cilic beat Roddick 6-4, 4-6, 6-4.

updated 12:34 a.m. ET July 25, 2008

TORONTO - Andy Roddick followed Roger Federer out of the Rogers Cup.

The sixth-seeded Roddick was upset by 44th-ranked Marin Cilic 6-4, 4-6, 6-4 Thursday and was later joined on the sidelines by fellow seeded players Nikolay Davydenko and David Ferrer, who were also eliminated.

“His aggressiveness is what won him that match,” Roddick said of Cilic. “He took it to me a lot more than I took it to him.”

Defending champion Novak Djokovic advanced to the quarterfinals with a 6-4, 6-4 win over Robin Soderling, and No. 2 seed Rafael Nadal moved on by beating Igor Andreev of Russia 6-2, 7-6 (1).

“I played more or less at the level which was satisfying for me,” Djokovic said.

With several top players already eliminated, the road to the final has been blown wide open.

“I just pay attention to my matches,” Djokovic said. “Having the role of a favorite in most matches I play, obviously I’m put in a lot of pressure. I have a lot of responsibilities and expectations, so it’s not easy.”

Roddick claimed he wasn’t looking past Cilic at a draw that no longer featured Federer in the way.

“I don’t know if I’m playing well enough right now to look ahead in the draw,” he said.

Gilles Simon, who upset the top-ranked Federer on Wednesday, advanced with a 6-3, 6-4 win over Jose Acasuso. Fourth-seeded Davydenko became another upset victim Thursday night when he dropped a 4-6, 6-4, 6-4 decision to Nicolas Kiefer, and No. 5 Ferrer was ousted soon after with a 6-3, 6-3 loss to 10th-seeded Richard Gasquet.

Four of the top six seeds have been eliminated.

Eighth-seeded Andy Murray of Britain advanced with a 6-2, 0-6, 6-4 win over ninth seed Stanislas Wawrinka of Switzerland, and No. 7 seed James Blake beat Dmitry Tursunov 4-6, 6-1, 6- Murray said he would have to be on top of his game against Djokovic.

“If I play the way I did in the first set, I have a chance of winning,” he said. “If I play like I did in the second set, I’m going to get killed.”

Cilic broke an indifferent-looking Roddick in the third and seventh games before taking the first set, despite a shaky 50 percent first-serve percentage.

Roddick rebounded in the second set, perhaps drawing inspiration from a crowd that was firmly in his corner. Amid occasional chants of “Go Andy Go” and “Let’s Go Andy,” the 25-year-old American played patiently, waiting for Cilic to make mistakes.

“(The) crowd helped him a little bit to get his mental side back,” Cilic said.

Roddick broke him in the eighth game and again in the 10th, when Cilic’s double fault evened the match and earned a fist-pumping Roddick a rousing ovation.

But the 19-year-old Cilic wasn’t fazed. He broke Roddick in the first game of the next set, and Roddick couldn’t get it back.

“I was moving him around quite good and exposing him on both sides,” said Cilic, ranked 44th in the world. “That was working very well. He obviously didn’t have a lot of chances to attack, which was a really good thing for me.”

Cilic, who will play Simon in the quarterfinals, said the win stands among the best of his career.

“You don’t have a chance to beat top 10 players every month, so it’s a good effort,” he said.

Nadal looked to have his game well in hand in the first set. Down 15-30 in the first game, Andreev rolled his left ankle. He took a timeout, got medical attention, and continued. Nadal then put him to work.

He kept Andreev on the run and placed his shots in the court with stunning accuracy.

Nadal faltered slightly in the second set, likely due to fatigue — he played twice Wednesday, in singles and a late doubles match — but ultimately found the energy to move on.

“I played a very good match, 100 percent better than yesterday,” he said.

Nadal wasn’t troubled by being forced to a second-set tiebreak.

“I know I’m going to have tough sets and tough matches,” he said. “So the 7-6 against Andreev is nothing strange. It’s completely normal.”

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