Feb. 6, 2005 — The New York Daily News reports Canseco says in his book, “Juiced: Wild Times, Rampant ’Roids, Smash Hits, and How Baseball Got Big” that he injected McGwire with steroids and introduced several other sluggers to the drugs.

March 5, 2005 — Commissioner Bud Selig announces that between one and two percent of the 1,183 drug tests done in 2004 were positive for performance-enhancing drugs. Per the old agreement, no names are released because no player tested positive twice.

March 17, 2005 — At a hearing of the House Government Reform Committee, McGwire evades questions about steroid use as he testifies alongside Canseco, Sosa and Rafael Palmeiro, who denies having used steroids. Lawmakers scold commissioner Bud Selig and union leader Donald Fehr, saying baseball’s penalties are too lenient. Some congressmen say legislation could be necessary.

April 3, 2005 — Tampa Bay outfielder Alex Sanchez becomes the first player suspended for steroids under the major league program.

April 4, 2005 — The league announces 38 minor leaguers tested positive for steroid use. By the end of the month, more than 50 minor leaguers have been suspended.

April 25, 2005 — Selig asks players to agree to a 50-game suspension for first-time steroid offenders, a 100-game ban for second offenders and a lifetime ban for a third violation.

July 15, 2005 — Conte and Anderson plead guilty to steroid distribution and money laundering, and Valente pleads guilty to one count of distributing illegal steroids.

Aug. 1, 2005 — Palmeiro is suspended for 10 days for testing positive for stanozolol, becoming the most prominent player to be penalized for steroids. Twelve players in all were suspended in 2005, each for 10 days.

Sept. 26, 2005 — Fehr counters Selig by proposing a 20-game suspension for first offense, a 75-game penalty for second and leaving the penalty for a third positive up to the commissioner.

Oct. 18, 2005 — BALCO’s Conte is sentenced to four months in prison and four months’ home confinement. Anderson receives three months in prison and three months in home confinement, and Valente gets probation.

Nov. 2, 2005 — Yankees outfielder Matt Lawton becomes the 12th and final player to be suspended 10 games after testing positive for a performance-enhancing drug. “I made a terrible and foolish mistake that I will regret for the rest of my life,” he tells The Associated Press.

Nov. 15, 2005 — Players and owners agree, subject to ratification, to Selig’s 50-game, 100-game, lifetime structure for penalties.

March 23, 2006 — Lance Williams and Mark Fainaru-Wada’s book Game of Shadows is released. Citing BALCO transcripts and court documents, the book details a massive steroid conspiracy in the game of baseball.

March 30, 2006 — Conte is released from prison and insists he never gave performance-enhancing drugs to Bonds, says the book Game of Shadows is “full of outright lies.”

April 13, 2006 — According to media reports, Bonds is under investigation by the U.S. government for perjury and tax evasion.

April 28, 2006 — Scientist Patrick Arnold pleads guilty to supplying BALCO with the performance-enhancing drug “the clear,” the once-undetectable substance tetrahydrogestrinone that Bonds allegedly told a grand jury he’d unknowingly used.

May 6, 2006 — Fainaru-Wada and Williams are called to testify before a federal grand jury investigating who leaked them the secret testimony of Bonds, Giambi and others. The authors fight the subpoenas.

June 7, 2006 — Federal IRS agents raid the home of relief pitcher Jason Grimsley, who admits using performance-enhancing drugs. According to a federal agent’s affidavit, Grimsley gives up the names of players who also have used the drugs.

Sept. 21, 2006 — Fainaru-Wada and Williams are ordered jailed for up to 18 months for refusing to comply with a subpoena ordering them to disclose their source. Jailing is stayed pending an appeal.

Oct. 1, 2006 — Roger Clemens, Andy Pettitte and Miguel Tejada are among the players that Grimsley accused of using performance-enhancing drugs, according to a federal agent’s affidavit, the Los Angeles Times reports.

Nov. 1, 2006 — Mets relief pitcher Guillermo Mota is suspended 50 days for violating the league’s drug policy, becoming the third and final suspended player of ’06. Grimsley and Mets minor leaguer Yusaku Iriki are the others.

Dec. 27, 2006 — Federal appeals court rules the names and urine samples of about 100 Major League Baseball players who tested positive for performance-enhancing drugs in 2003 can be used by investigators.

Feb. 15, 2007 — Troy Ellerman, who once represented Conte and Valente, pleads guilty to being the Chronicle’s source of secret grand jury testimony and faces up to two years in prison. The government withdraws its subpoenas of Fainaru-Wada and Williams.

April 26, 2007 — Former New York Mets clubhouse worker Kirk Radomski pleads guilty to selling performance-enhancing drugs to major leaguers. He cooperates with authorities, testifying before the same grand jury investigating Bonds.

Aug. 4, 2007 — Tigers shortstop Neifi Perez is suspended 80 games after testing positive a third time for stimulants. The harshest penalty handed out yet for drug use is not for a steroid, but the harsh penalty is due to the league’s crackdown on performance-enhancing drugs.

Oct. 31, 2007 — Outfielder Mike Cameron is suspended 25 games after testing positive a second time for a banned stimulant. “No steroids,” Cameron tells a radio station. “I never took nothing like that before in my life. That would be 50 games, and that would affect me a whole lot more.”

Nov. 1, 2007 — Bonds tells MSNBC he will boycott Cooperstown if the Hall of Fame displayed his record-breaking home run ball with an asterisk. “There’s no such thing as an asterisk in baseball,” Bonds said.

Nov. 15, 2007 — Bonds is indicted on five felony counts of perjury and obstruction of justice for allegedly lying when he testified he never knowingly used performance-enhancing drugs. If convicted, legal experts say Bonds could spend up to 2½ years in prison.

Nov. 27, 2007 — Relief pitcher Dan Serafini becomes the second player suspended in ’07 specifically for performance-enhancing drug use. Tampa Bay pitcher Juan Salas was the first. Serafini, formerly with the Rockies and now a free agent, will miss the first 50 games of the 2008 season.

Dec. 6, 2007 — Outfielders Jose Guillen and Jay Gibbons, linked in media reports to receiving human growth hormone, are suspended for the first 15 days of the 2008 season.

Dec. 7, 2007 — Bonds pleads not guilty to four counts of perjury and one of obstruction of justice.

Dec. 10, 2007 — The players’ association files a grievance to overturn Guillen’s 15-day suspension. Gibbons has chosen not to contest his penalty.

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