Marcio Jose Sanchez / AP

Barry Bonds belts a two-run home-run off Rockies pitcher Taylor Buchholz in the sixth inning Sunday. Bonds had not homered in 63 plate appearances.

“It’s a place that hasn’t been very friendly with us,” manager Clint Hurdle said of the Giants’ waterfront ballpark. “We were able to back up a good first series on the road in Arizona with a better one here. That was our focus when we left. Now our focus will be to go and have a good homestand, which we need to do.”

Matt Holliday hit a go-ahead two-run triple in the fifth. Buchholz, trying to beat the Giants for the first time in three May tries, struck out five and didn’t walk a batter in seven innings — matching his longest outing of the year, which he also did in his previous start May 19 against Kansas City.

Helton added a run-scoring single and Iannetta tripled in a run.

Bonds flied out to left leading off the second then singled to left-center to start the fourth to end his 0-for-17 funk. He stole his second base moments later for No. 511 of his career. Bonds reached third on Molina’s groundout, but the Giants couldn’t drive him home.

After Bonds’ single, Buchholz retired the next seven San Francisco hitters in order before Rich Aurilia’s infield single in the sixth. Bonds followed with the homer.

“He’s very dangerous no matter what,” Buchholz said. “That’s why he’s probably the best hitter of all time.”

Bonds is scheduled to get a break Tuesday night, when the Giants open a three-game series at Shea Stadium — though manager Bruce Bochy left open the possibility that he’d change his mind and write No. 25 into the lineup. Bonds was looking forward to nearly three full days to let his body recover, though he feels good but is just a little tired.

“Unless he changes his mind,” Bonds said of playing the series opener. “That’s OK, though. I’m up for the challenge.”

Notes: Bonds had a 21 at-bat hitless stretch from April 5-12, 2001 — the year he broke the single-season home run record with 73 — and had a career-worst 0-for-23 drought from July 6-20, 1986, during his rookie year, according to the Elias Sports Bureau. ... Giants 2B Ray Durham, injured Saturday night, had an MRI exam on his strained abdominal muscle and could be headed for the disabled list.